With China’s economy entering the new formal driven by innovation, to build the cooperative tackle-key-problems system of industry-university-research-user, with the core of company, has become the main path selection to transform from the old energy to the new one. This paper describes the five characteristics for the cooperative tackle-key-problems system of industry-university-research-user through the case study, expounds it’s main driving factors and process, and then proposes an integral framework of mechanism. And this paper depicts its process led by one of driving factors with the other two factors functioning one by one, so these three factors propel its spiral rise by self-reinforcing mechanisms over time. And finally, some meaning experiences and enlightenments have summarized. This study can provides reference and lessons for the focal companies to build the cooperative tackle-key-problems system of industry-university-research-user.