Based on the two-sector innovation production model, a theoretical model for the integration of informatization and industrialization to influence industrial innovation efficiency was constructed. The panel regression and threshold regression methods were used to prove that the promotion effect of the integration of informatization and industrialization on the efficiency of industrial innovation is not simply linear, but has also experienced two incremental mutations as the level of integration of informatization and industrialization has increased. Further research shows that this mutation is caused by the constraints of different external environmental levels. In the sample interval, the promotion of integration of informatization and industrialization on industrial innovation efficiency has two incremental mutation with the improvement of informatization level, and one incremental mutation with the improvement of industrialization level and degree of economic openness.