The development of the organization is inseparable from the guidance of entrepreneurship and the support of employees' innovative behavior. The study explores the effect of the superior entrepreneurship on subordinates' innovative behavior from the perspective of interpersonal interaction. A theoretical model with superior entrepreneurship as independent variable，the employees' work engagement as mediating variable，the subordinates' innovative behavior as dependent variable and leader-member exchange as moderating variable is established. The results of multi-level analysis show that the direct entrepreneurial spirit has a significant positive impact on; the employees' work engagement plays an intermediary role between superior entrepreneurship and the subordinate's innovative behavior; and the leader-member exchange plays a moderating role between the employees' work engagement and innovative behavior.