Innovation-driven is the breakthrough to solve the unbalanced and inadequate development in China, which is also the booster of high-quality development. Using the panel data of 30 provinces and cities in China from 2003 to 2017, we adopt the Global-Malmquist Model to measure the high-quality development level of China, and evaluate the balanced development and the adequate development level of every province and city in China by constructing the index systems. Then we analyze the mechanism of innovation-driven influence on high-quality development at different levels of balanced and adequate development with Threshold Regression Model. The results show that：1) The region"s high-quality development level shows the tendency of declining at the begining and rising up in late; 2) The balanced and adequate development level of every province and city takes on an upward trend, but there are big differences between provinces and cities, which has a obvious spatial agglomeration feature; 3) Under different level of balanced and adequate development, the mechanism of innovation-driven influence on high-quality development is different. The innovation-driven has no significant impact on high-quality development when the level of balanced and adequate development is low; when balanced and adequate development reaches a certain level, innovation-driven plays a certain role in promoting high-quality development; with the further improvement of balanced and adequate development level, innovation-driven’ s contribution to promoting high-quality development has become more and more important.