Applying blockchain technology to the field of information sharing in industrial technology innovation alliances can solve the security issues of alliance information sharing, increase the willingness of alliance entities to share information, deepen the degree of information sharing, and thereby improve the efficiency of alliance information sharing. Using the evolutionary game method, constructed an information sharing game model between the enterprises and the universities and research institutes of the industrial technology innovation alliance, and made a concrete analysis of the results and evolutionary logic of the five factors that affected the information sharing decisions of both the government and block incentives, punishment, marginal cost, and risk coefficient, through matlab simulation. The results indicate that compared to the information sharing process of traditional industrial technology innovation alliances, the application of blockchain technology has a significant impact on the key parameter values of various factors in its sharing process, making it easier for both parties to achieve an ideal equilibrium state of shared information. However, the influence level of each factor varies. Conditional alliances should focus on the integration of blockchain technology and alliance information sharing networks, develop appropriate factor combination collaboration strategies based on actual situations, and promote the sustainable and high-speed development of the alliance.