Service quality and customer loyalty has a positive impact for enterprises to gain competitive advantage. Guanxi, as a unique element in Chinese enterprise management, is receiving more and more attention. Revealing the internal relationship between the three factors is very important for improving the performance of service enterprises and enriching the Chinese theory. This paper takes the service industry as the research object and studies the impact of service quality and Guanxi on customer loyalty. The results of data analysis show that the service quality of the enterprise and Guanxi between the customer and the service personnel positively affect the customer's loyalty to the enterprise. The service quality of the enterprise helps to enhance the Guanxi between the customer and the service personnel. In the case of high corporate consistency, Guanxi between the customer and the service personnel has a greater impact on the customer's loyalty to the enterprise. These results have certain sense for enhancing customer loyalty, and also can help to enrich the localization theory in the Chinese context.