In this paper, using Fuzzy Set Qualitative Comparative Analysis (fsQCA), 35 cities in China's cross-border e-commerce comprehensive trial area are selected as the basic group, and 35 top 100 foreign trade cities are selected as the control group to explore the factors affecting the location selection of cross-border e-commerce comprehensive trial area and the path of pilot promotion. It is found that the location choice of cross-border e-commerce comprehensive trial area does not depend on a single condition, but is the result of the combination of different preconditions; there are four different paths leading to the establishment of comprehensive trial area, according to the core conditions of the configuration, it can be divided into two modes: policy-oriented mode and industry-supported mode; among them, the former one is policy-oriented mode. The core conditions are government scale and foreign investment participation, which is reflected in the construction of Cross-border e-commerce Comprehensive trial area under the guidance of foreign investment and talent linkage; the core conditions of the latter are regional trade concentration, e-commerce development basis and industrial structure, which is reflected in the promotion of Cross-border e-commerce Comprehensive trial area construction by the interaction of e-commerce and services under the role of regional nodes. Combined with the empirical results, we will provide theoretical support for the construction and promotion of comprehensive trial areas in China, so as to better serve the Trade Power and the "One Belt and One Road" construction. Key words: Cross border e-commerce Comprehensive Trial Area; location choice; pilot promotion; fuzzy set qualitative comparative analysis