As an important subject of scientific and technological innovation, colleges and universities play an increasingly important role in the construction of regional innovation system. Based on the provincial panel data of 2008-2017, this paper studies the coupling coordination relationship between scientific and technological innovation in colleges and universities and regional economic development. Then, it analyzes the spatial correlation and agglomeration of the coupling coordination degree from the perspective of geographical proximity. The results show that scientific and technological innovation in colleges and universities and regional economic development are highly coupled and the coordination degree increases with time. The overall coordination degree presents the layout of "high in the East, low in the west, high in the South and low in the north". In addition, there is a positive spatial autocorrelation between the coupling coordination degree of scientific and technological innovation in colleges and universities and regional economic development, and different aggregation areas show certain contraction and expansion in the evolution of time and space.