We selected Google's intelligent driving ecosystem as a case study object in order to analyze the evolution process of ecosystems in the breakthrough innovation，and discussed how to realize breakthrough innovation through ecosystem construct. The results show that in order to overcome the high non-equilibrium dependence and weak joint dependence in the R&D period of breakthrough technology, enterprises choose strong structure embedding and strong relationship embedding in the stage of knowledge materialization to enhance joint dependence. From the stage of knowledge materialization to the stage of commercialization, enterprises maintain the advantages of structure hole size, enhance the heterogeneity of system members, and choose the way of weak relationship embedding to reduce the two dependencies, so as to achieve the commercialization of breakthrough technology. This article has established a theoretical model of “system structure-resources\network-breakthrough innovation”.