It is the main way for traditional manufacturing industry to transform and upgrade through the manufacturing sertivization. Taking China’s manufacturing industry listed companies as the research object, we empirically tests the impact of manufacturing sertivization on enterprise performance. And the results show that the manufacturing sertivization can significantly improve the enterprise performance. In this process, government subsidies play a positive regulatory role. Further analysis shows that such positive regulatory effect is more obvious in state-owned enterprises, experienced enterprises and coastal enterprises. Therefore, the key to improve the service performance of manufacturing enterprises is to fully consider the differences of enterprises’ characteristics and build a reasonable and effective government subsidy mechanism.