With the rapid changes in market demand and the external environment，enterprises need to manage and combine their own technological resources，and attach importance to the acquisition of knowledge through external way to expand the scope of technological base，so as to complement persistent innovation. From the perspective of knowledge collaboration among organizations，the issue of how enterprises’technological diversification strategy，including internal technological diversification and external technological diversification，influences the collaboration of knowledge among the organizations，and then brings to the persistence of innovation，is discussed. The empirical research results show as follows. Both the internal technology diversification and external technology diversification have positive impact on the persistence of enterprise’s innovation. All three dimensions of knowledge collaboration among organizations play an intermediary role in the relationship between technology diversification and the persistence of the innovation. The capabilities of coordination and integration has a positive moderating effect on the relationship between external technology diversification and the persistence of the enterprise’s innovation.