“Urban Talent War” has become more and more fierce. Highlighting talent is an important engine of urban development, and innovation is the first driving force for development. So, how does human capital affect regional innovation efficiency? What is the difference between human capital and innovation efficiency in different provinces and cities? This paper uses the 2011-2017 panel data of 30 provinces, with the help of a panel stochastic frontier model to measure the efficiency of regional innovation in our country. And in SARAR spatial econometric model analyzes the influence of human capital on regional innovation efficiency. Studies have shown that capital investment can significantly improve the efficiency of innovation and China"s regional innovation efficiency in the stage of weak returns to scale. It also points that regional technological innovation efficiency have obvious differences, human capital and innovation efficiency significantly positive correlation. Finally, based on the empirical conclusion, it puts forward some policy suggestions about innovation and talent administration.