Since the reform and openness, Zhejiang and Guangdong have achieved rapid development of their economy. But inter-regional labor mobility follow different pattern between Zhejiang Province and Guangdong Province, mainly in the direction of inter-province labor mobility, level of edueation and the distribution of occupations of immigration. This paper begins from the different path of the eCOnomic openness between the two provinces. Through comparing the difference in main investor, industrialization path and specialization between the two provinces, we analysis the more profound reasons which impel the labor mobility and make some reasonable explanation of labor mobility differences of the two provinces.