This study determined the Key Factors of Cross-cultural Management Mechanism Structure for Foreign Enterprises in International Entrepreneurship. The Results from the empirical study were as follows: 1. Cross-cultural Management Executive Mode had immediate impact on Integral Organizational Performance. 2. In the Dynamical Functioning of Cross-cultural Management Mechanism, Cross-cultural Cooperative Mode and Human Resources Management had indirect but vital impact through moderating the Effect of Management Executive Mode to Integral Organizational Performance. 3. All Factors in Cross-cultural Management Executive Mode and Cross-cultural Cooperative Mode, with Most Factors in Cross-cultural Human Resources Management among foreign enterprises coming from Western Countries and Hong Kong/ Taiwan Regions had significant differences, resulting in significant differences of Integral Organizational Performance.