The emerging of the knowledge economy has made a great impact on the colleges and universities of our country, so the teaching reform is an important respect that promotes the colleges and universities to get hold of the opportunity. This paper, first of all, analyzes the urgency of the teaching reform of colleges and universities in the knowledge- driven economy era, and then discusses how to carry on the teaching reform and cultivate innovative talents in several ways, such as the innovation of teaching content and teaching method and fully bring into play the role of teachers, etc.