Based on the investigation of 1148 employees of 80 enterprises in Guizhou, Guangdong and Fujian provinces, an intermediary model was built based on the positive impact of employees on corporate social responsibility and leadership behavior perception on human resource management efficiency. The research in this paper finds that the connotation of corporate social responsibility at the micro level of the organization has been paid more and more attention by enterprises. To realize the corporate social responsibility of employees from the output demand to the investment perspective, it has become the reference standard system for enterprises to meet the work needs and working resources of employees. The company regards these employees as corporate social responsibility as the need of work and the needs of work resources. The employees can effectively improve the efficiency of human resource management. The study found that corporate social responsibility affects the efficiency of human resource management from corporate economic responsibility, legal responsibility, ethical responsibility and discretionary responsibility; transformational leadership and transactional leadership have a synergistic role in corporate social responsibility and human resource management effectiveness. The research conclusion has important theoretical and practical significance for the matching of corporate social responsibility, leadership behavior and human resource management.