High-quality research achievement is not only the career pursuit of most teachers, but also represents the core competitiveness of universities in higher education. Scientific design of incentive mechanism for research outcome can help to promote the win-win situation. This paper aims to discuss the incentive mechanism of research achievement based on analyzing the key factors influencing research achievement, and then stimulate the initiative of university teachers to do scientific research in combination with their majors and create more educational value. Based on the principal-agent theory, this paper constructs the incentive model through analysis, works out the Optimal Incentive Contract and related influencing factors as the teachers’ efforts could not be observed. The results show the following research findings. Firstly, the teachers optimal benefit is positively related to the initial pay level, platform environment, incentive level and output efficiency, negatively related to research difficulty. Secondly, universities optimal benefit is positively related to platform environment, units output gains, negatively related to initial pay level.