There is no unified conclusion in academe on the impact of quality management practices on enterprise innovation performance. This study divides Quality management practices are divided into the basic practices and the core practices. Based on the resource-based theory, a dual mediation model from quality management practices to enterprise innovation performance is established, introducing two mediators, enterprise resource endowment and organizational inertia., And 20 hypotheses are proposed and are tested with the 204 samples. The research results show that quality management practices not only positively affect enterprises innovation performance through the mediator of enterprise resource endowment, but also negatively affects enterprises innovation performance through the mediator of organizational inertia. The simultaneous existence of positive and negative paths is the root of conflicts in previous conclusions. This paper explains The reasons why the academe has a heterogeneous view on the role of quality management practices in corporate innovation performance,are explained which and enriches the local research on the role of quality management practices in enterprise innovation performance.