To fully understand global value chain (GVC)’s macroeconomic effect, this paper explores the impact of global value chain on international business cycle synchronization based on the data of 102 countries from 2000 to 2014. The results show that trade through GVC has greatly enhanced international vertical division and generates positive impact on the international business cycle synchronization significantly. Whether manufacturing or service industries, has shown a significant and positive impact on international business cycle synchronization, indicating service industries has more and more deeply integrated into the global labor division system. The effect of GVC trade on the international business cycle synchronization is mainly founded between developing and developed economies, while not significant between developed economies.