s:Based on the panel data of 30 provincial administrative regions from 2014 to 2019, starting from the theoretical mechanism of innovation and entrepreneurship to promote innovation efficiency, this paper constructs an indicator system to measure innovation efficiency according to the goal-oriented innovation and entrepreneurship, and uses DEA model and super efficiency DEA model to evaluate provincial innovation efficiency respectively. The results show that: the provincial innovation efficiency shows a U-shaped development trend, and overall shows an upward trend. Innovation and entrepreneurship can effectively improve the innovation efficiency. There are differences in innovation efficiency among provinces, but the reasons for DEA inefficiency are different. The eastern region has higher innovation efficiency, followed by the western region, the central region and the northeast region. In order to further improve the innovation efficiency, we should strengthen the linkage of innovation and entrepreneurship while increasing the investment in innovation and entrepreneurship and improving the business environment.