Online interaction plays an important role in improving the effect of cross-border marketing. In order to understand the logic behind the customer consumption cross-border products, based on the CAS theory to build the cross-border marketing effect under the influence of the online interaction behavior model of computational experiment method is applied to simulate the enterprise guide under the perspective of incentive factors, emotional factors, network characteristics and comprehensive guide the strategy how to through online interaction affect the evolution of the cross-border marketing effect. The results show that incentive intensity has a positive effect on sales performance of cross-border products, but has no significant effect on brand equity performance. Emotional guidance has a positive effect on sales performance and brand equity performance of cross-border products. Network relationship is helpful to the diffusion of cross-border products and the improvement of brand equity performance, but the effect of network scale is uncertain. The overall performance of comprehensive guiding strategy is better than that of single guiding strategy. The conclusion of this study has certain reference value for enterprises participating in cross-border marketing to enhance the effect of cross-border marketing.