From the perspective of major national strategic regions，this paper measures the spatial imbalance characteristics of China''s digital inclusive finance development by using Theil index, and explores its causes based on QAP method. The conclusion shows that the spatial imbalance of China''s digital inclusive finance development shows a downward trend in major national strategic regions, and the regional difference is the main source of its spatial imbalance. The regional gaps in the regional economic development, traditional financial foundation and digital technology have enhanced the spatial imbalance of China''s digital inclusive finance development. And the regional gap in the regional economic development plays the most important role, which is the decisive factor for the spatial imbalance of digital inclusive finance in the Yangtze River Economic Belt, the Yangtze River Delta and Beijing-Tianjin-Hebei Region. On the same time, urbanization is the decisive factor for the spatial imbalance of digital inclusive finance in Yellow River Basin. In order to promote the regional coordinated development of digital inclusive finance, we should objectively treat the spatial imbalance characteristics of China''s digital inclusive finance development, and make accurate measures according to local conditions.