AI (Artificial Intelligence) is changing service encounters and improving service productivity. Humanoid service machine is more stable than service employees, and more adaptive than SSTs. Field evidence is provided through data mining based on online review in study 1; Experiment materials are designed based on real hotel service interactions in two pilot studies; The main effect of machine anthropomorphism on customer acceptance intention is verified in study 2; Mediating effects of agency and experience are explored through survey-experiment from mind perception perspective in study 3; The moderating effect of gender role is explicated in study 4. Results show that: AI machine with anthropomorphism is more likely be accepted by subjects in hotel service interactions; Based on mind perception theory, agency and experience have parallel mediating effects on the relationship between anthropomorphism and acceptance intention; Masculinity has no significant effect on the mediating mechanism of agency; Femininity is a mediated moderating variable, which has negative moderating effect on the relationship between anthropomorphism and experience. Therefore, subjects with more femininity are less likely accept anthropomorphic machine through experience. The contribution of AI machine anthropomorphism is amplifed in service marketing, the application of mind perception theory is broaden, and the potential negative effect of anthropomorphism is supplemented. Practical implication for the AI machine design and the utilization of anthropomorphism are also provided.