With the acceleration of China"s economic construction process, various regions have accelerated the introduction of innovation-driven strategies and innovative ecological policies. Especially for Resource-based Regions, facing the dual constraints of resources and the environment, and the serious "system resistance effect", it is urgent to use innovative ecological strategic policies to promote the economy to break through the resource lock-in effect and embark on the road of high-quality development. Based on the perspective of MLP (multi-level perspectives), construct a regional innovation ecosystem from the perspectives of innovation niche, innovation system and innovation landscape. Build a theoretical model that affects the high-quality development of resource-based regions. Taking 26 resource-based regions as examples, using fsQCA And NCA method to analyze the complex causal mechanism of innovation ecosystem construction with multiple influencing factors affecting the high-quality economic development of Resource-based Regions. It was found that there are three paths to drive the high-quality development of Resource-based Regions: innovation niche kinetic energy development transformation, system-driven transformation, and innovation environment-driven transformation. There are four paths to drive the non-high-quality development of resource-based regions: the overall factor-poor type, the resource-policy inhibition type, the resource-policy-industrial regulation inhibition type, and the resource-environment deficiency type. The main body of innovation plays a universal role in the high-quality development of resource-based regions, and policy-driven is an important driving force for promoting the high-quality development of resource-based regions. The infrastructure and innovation environment need to synergize with other conditions to achieve better results. The conclusions have important theoretical and practical significance for revealing the diversified paths of high-quality development in Resource-based Regions.