In recent years, the United States has upheld a science and technology blockade strategy on China and imposed technology blockade on the relevant high-tech companies and related industries in accordance with the Regulations on Export Control (EAR), in an attempt to restrain innovative development in our country. In this paper, panel data of listed companies were constructed according to the entity list published by EAR. The time-varying point DID model was used to study the actual impact of the US technology blockade event on China''s innovation output, and the heterogeneity of processing effects that might exist in the model was considered. The research shows that the science and technology blockade strategy of the United States inhibits Chinese innovation output in the short term, but the relevant technology blockade measures have a negative role in promoting Chinese innovation output in the long term. Secondly, science and technology containment will have an adverse impact on our innovation output by increasing technological distance, decreasing output effect and reducing trade effect. In light of the current situation in China, China should unswervably adhere to the strategic goal of innovative development. At the same time, China should actively make use of international cooperation mechanisms to explore the possibility of establishing new economic and trade rules of the international community with other countries, and respond to the impact of the US technology blockade on China''s innovative development in various ways.