Healthcare big data is an important basic strategic resource in China, and it is important to accurately identify the influencing factors of data asset value realization process. This study proposes the value realization path of "data generation-asset formation-value realization-data regeneration" from the perspective of information ecosystem, takes data producers, data intermediaries, data developers and data consumers as information subjects, and considers legal, economic, technological and social environmental factors to build the value realization model of healthcare big data assets. After having sorted out the influencing factors of value realization of healthcare big data assets and their correlations, we simulate the value realization path according to Vensim PLE simulation results. From the simulation results, under different social security mechanisms, the degree of legal improvement has the most significant impact on the amount of value realization of healthcare big data assets. Meanwhile, the level of technology, the degree of health care data sharing and the strength of health care-related capital investment also have a greater impact on the amount of asset value realization. We propose several ways to promote the maximization of the value of healthcare big data assets from the perspectives of promoting the improvement of technology level, improving legal policies and promoting market demand.