Guiding the rational transfer of industry plays an important role in cracking the contradictions of unbalanced and inadequate development in China. The trans-regional transformation of scientific and technological achievements has gradually become an important way of industrial transfer in recent years, but there is still a big gap in its scientific understanding. Using the multi-case grounded theory research method, this study analyzes the new patterns and core driving force of trans-regional transformation of scientific and technological achievements and industrial transfer through case studies of typical projects undertaken by some western provinces and cities in recent years. It is found that the cross-regional transformation of scientific and technological achievements is an effective way to promote industrial transfer, which is mainly manifested in four new patterns, namely Incremental capacity transfer、Computing power data transfer、Extended chain collaborative transfer and Achievement incubation transfer transfer. The driving force mainly comes from market driving force, labor division remodeling force and institutional force. On this basis, this paper constructs the realization path model of trans-regional transformation of scientific and technological achievements to promote industrial transfer, and provides theoretical support and path suggestions for the western region to undertake the practice of industrial transfer through trans-regional transformation of scientific and technological achievements.