Based on 172 Chinese and English empirical studies, this paper adopts the meta-analysis method to firstly investigate the role of corporate social responsibility(CSR) on corporate innovation, and then deeply explore the moderating effect of potential moderating factors. The study shows that CSR has a significant positive impact on corporate innovation, and the relationship is moderated by cultural background, firm size, measurement method and innovation measurement method. Specifically, the influence of CSR on corporate innovation is more significant in western culture than in eastern culture; The correlation between CSR and corporate innovation is stronger in small and medium-sized enterprises than in enterprises with large scale; The fulfillment of CSR is more beneficial to corporate innovation with subjective measurement than with objective measurement; And the positive influence of CSR on innovation output is greater than that on innovation input. The above research findings provide effective guidance for enterprises to carry out social responsibility practices and innovation management.