As the key driving force for enterprises to achieve the goals of improving quality and efficiency and building competitive advantages, how to effectively cultivate the craftsman spirit of organizational members has become a topic discussed by the academic community and the industry. Based on self-determination theory, a multilevel moderated mediating model including affective leadership, basic psychological needs satisfaction, future work self-salience and employees’ craftsman spirit was constructed. The results of the empirical analysis of the data collected through a two-point approach show that affective leadership positively influences the cultivation of employees'' craftsman spirit; affective leadership indirectly influences employees’ craftsman spirit through basic psychological needs satisfaction; future work self- salience not only positively moderates the relationship between affective leadership, basic psychological needs satisfaction and employees’ craftsman spirit, but also positively moderates the mediating role of basic psychological needs satisfaction. The article clarifies the inner mechanism between affective leadership and employees’ craftsman spirit, and provides guidance for organizations to effectively cultivate craftsman spirit.